Lynch syndrome Module 2 training test for Gynae MDT

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1. Question 1.

What is your name?

Required - Required.

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2. Question 2.

In additon to Endrometrial cancer, does Lynch syndrome predispose to a variety of other cancers?

Required - Required.

No

Yes, Like for instance colorectal, ovarian, urinary tract, gastric, small intestine, bone and breast cancers

Yes, Like for instance colorectal, ovarian, urinary tract, gastric, small intestine, hepato-biliary, sebaceous and CNS cancers

Yes, Like for instance colorectal, breast and bone cancers

Yes, Like for instance colorectal, liver, lung and breast cancers

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3. Question 3.

Approximately, how many inherited endometrial cancers are caused Lynch syndrome?

Required - Required.

30%

Not known

10%

10 to 30%

3%

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4. Question 4.

How many genes have been associated with Lynch syndrome?

Required - Required.

4

3

6

5

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5. Question 5.

Which tests can be performed to check is the tumour is deficient MMR (dMMR)? (only select one answer)

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None

IHC or MSI

BRAF

Microsatellite instability (MSI) and hypermethylation

Immunhistochemistry (IHC)

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6. Question 6.

Who should have MMR IHC testing?

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All newly diagnosed endometrial cancer patients under the age of 70y

All newly diagnosed endometrial cancer patients under the age of 50y

All newly diagnosed endometrial cancer patients. Testing should only be done on surgical tumour sample

All newly diagnosed endometrial cancer patients. Testing should be done on the earliest possible biopsy

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7. Question 7.

The cancer risk in Lynch syndrome can be managed by:

Required - Required.

Surgery

Lifestyle recomendations

Regular colonoscopy with polypectomy

All of the above

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8. Question 8.

What is the inheritance pattern in Lynch syndrome?

Required - Required.

Autosomal dominant: 1st degree relatives have a 25% risk of having the same condition

Autosomal recesive: 1st degree relatives have a 50% chance of having the same condition

Autosomal dominant: 1st degree relatives have a 50% chance of having the same condition

Autosomal recesive: 1st degree relatives have a 25% chance of havinf the same condition