Lynch syndrome Online training for pathologists M2 EC

1. What is your name? *

2. What is your job title? *

3. In which Hospital and Trust do you work? *

4. What is your email address? *

5. What is your cancer alliance? *

6. What is your GMSA? *

7. Why are you undertaking this training? *

8. Which MDT do you work with? *

Colorectal cancer
Endometrial cancer
Both

9. What does it mean if the MMR IHC results are normal? *

Diagnosis of Lynch syndrome is unlikely - Refer to genetics if there is a significant family history
Diagnosis of Lynch syndrome is likely - Offer genetic testing
Diagnosis of Lynch syndrome is unlikely - Nothing further to consider
Diagnosis of Lynch syndrome is possible - Order MLH1 promoter Methylation

10. Is the MMR IHC results show that there is isolated loss of PMS2, what does it mean? *

Diagnosis of Lynch syndrome is unlikely - Refer to genetics if there is a significant family history
Diagnosis of Lynch syndrome is likely - Offer genetic testing
Diagnosis of Lynch syndrome is unlikely - Nothing further to consider
Diagnosis of Lynch syndrome is possible - Order MLH1 promoter Methylation

11. If the IHC result show that there is a loss of MLH1 and PMS2, what does it mean? *

Diagnosis of Lynch syndrome is unlikely - Refer to genetics if there is a significant family history
Diagnosis of Lynch syndrome is likely - Offer genetic testing
Diagnosis of Lynch syndrome is unlikely - Nothing further to consider
Diagnosis of Lynch syndrome is possible - Order MLH1 promoter Methylation

12. If the MMR IHC result show that there is loss of MSH2 and MSH6, what does it mean? *

Diagnosis of Lynch syndrome is likely - Offer genetic testing
Diagnosis of Lynch syndrome is unlikely - Refer to genetics if there is a significant family history
Diagnosis of Lynch syndrome is possible - Order MLH1 promoter Methylation
Diagnosis of Lynch syndrome is unlikely - Nothing further to consider

13. The MMR IHC result showed that there is loss of MLH1. You ordered further MLH1 Methylation in the tumour sample. The result shows that there is "abnormal MLH1 methylation" present (methylation is present). What does it mean? *

Diagnosis of Lynch syndrome is likely - Offer genetic testing
Diagnosis of Lynch syndrome is unlikely - Refer to genetics if there is a significant family history
Diagnosis of Lynch syndrome is unlikely - Nothing further to consider

14. When would you use this report?
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15. When would you use this report?
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16. When would you use this report?
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