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Lynch syndrome Module 2 training test
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1.
Question 1.
What is your name?
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- Required.
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2.
Question 2.
Does Lynch syndrome predispose to a variety of extra-colonic cancers?
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- Required.
Yes, Like for instance endometrial, ovarian, urinary tract, gastric, small intestine, hepato-biliary, sebaceous and CNS cancers
Yes, Like for instance endometrial, liver, lung and breast cancers
Yes, Like for instance endometrial, breast and bone cancers
Yes, Like for instance endometrial, ovarian, urinary tract, gastric, small intestine, bone and breast cancers
No
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3.
Question 3.
6. Approximately, how many inherited CRC are caused Lynch syndrome?
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- Required.
3%
10%
30%
10 to 30%
Not known
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4.
Question 4.
How many genes have been associated with Lynch syndrome?
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- Required.
6
4
5
3
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5.
Question 5.
Which tests can be performed to check is the tumour is deficient MMR (dMMR)? (only select one answer)
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- Required.
None
BRAF
Immunhistochemistry (IHC)
IHC or MSI
Microsatellite instability (MSI) and hypermethylation
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6.
Question 6.
Who should have MMR IHC testing?
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- Required.
All newly diagnosed CRC patients under the age of 70y
All newly diagnosed CRC patients. Testing should be done on colonoscopic or earliest possible biopsy
All newly diagnosed CRC patients. Testing should only be done on surgical tumour sample
All newly diagnosed CRC patients under the age of 50y
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7.
Question 7.
The cancer risk in Lynch syndrome can be managed by:
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- Required.
Surgery
Lifestyle recomendations
Regular colonoscopy with polypectomy
All of the above
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8.
Question 8.
What is the inheritance pattern in Lynch syndrome?
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- Required.
Autosomal dominant: 1st degree relatives have a 25% risk of having the same condition
Autosomal recesive: 1st degree relatives have a 50% chance of having the same condition
Autosomal recesive: 1st degree relatives have a 25% chance of havinf the same condition
Autosomal dominant: 1st degree relatives have a 50% chance of having the same condition