Lynch syndrome Module 3 training test for Gynae MDT

 

1. What is your name? *

 

2. What does it mean if the MMR IHC results are normal?
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3. If the MMR IHC results show that there is isolated loss of PMS2, what does it mean?
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4. If the IHC result show that there is a loss of MLH1 and PMS2, what does it mean? *

 

5. If the MMR IHC result show that there is loss of MSH2 and MSH6, what does it mean?
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6. The MMR IHC result showed that there is loss of MLH1. You ordered further MLH1 Methylation in the tumour sample. The result shows that there is abnormal MLH1 methylation present. What does it mean? *

 

7. The MMR IHC result show that there is loss of MLH1. The MLH1 promoter hypermethylation shows: "MLH1 promoter methylation is not detected". What does it mean? *